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invivoCrown IV0117替换BioXCell BE0223 invivoCrown IV0117替换BioXCell BE0223
InVivoPro Anti-Mouse CD8β (Lyt 3.2) in vivo antibody, Clone 53-5.8 ...
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InVivoPro Anti-Mouse CD8β (Lyt 3.2) in vivo antibody, Clone 53-5.8 ...
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invivoCrown IV0106替换BioXCell BE0090 invivoCrown IV0106替换BioXCell BE0090
InVivoPro Rat IgG2b in vivo Isotype control ...
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Allele Biotechnology.jpg

Allele Biotechnology位于美国圣地亚哥市,主要专注于对生物过程的机制进行探索,以开发生物医学及治疗相关的技术和产品。以各个物种的iPS细胞、人类cGMP iPS细胞及衍生的细胞为材料,Allele Biotechnology利用专利性的非整合细胞编辑方法,开发了出了细胞治疗和药物筛选的技术。Allele Biotechnology具有深厚的基因组修饰和细胞荧光报告因子的经验,为客户提供优异的细胞检测解决方案。Allele Biotechnology还提供荧光蛋白、高效荧光素酶底物、基因分型试剂盒、骆驼抗体等产品;此外还在RNA干扰领域尤其独特的专利。

 

Allele Biotechnology and Pharmaceuticals, Inc. is a private, San Diego-based company that explores the mechanisms of biological processes to develop technologies and products for biomedical research and therapy development.

 

Our mission is to increase accessibility to innovative molecular biology research tools by offering cutting edge technologies in individual products and fully integrated platforms. Allele utilizes proprietary non-integrating cellular reprogramming methods to develop cell therapy and enable drug discovery through the use of human and non-human primate iPS cells, cGMP-grade human iPS cells and their derivatives. With additional expertise in genome modification and unique cell-based fluorescence sensors/reporters, Allele provides advanced cell and assay development solutions. Allele also has developed a wide variety of advanced research tools including superior fluorescent proteins, highly efficient luciferase assay substrates, genotyping kits, and camelid antibodies that have been validated for co-immunoprecipitation, histology, and flow cytometry. The Company has also been a leader in the RNAi field with its patents in Pol III promoter-driven siRNA, shRNA, and miRNA.

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Allele Biotechnology
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InVivoPro Anti-Mouse CD40 in vivo antibody, Clone FGK45 ...
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InVivoPro Anti-Mouse CD8α in vivo antibody, Clone 2.43 ...
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InVivoPro Anti-Mouse PD-L1(B7-H1, CD274) in vivo antibody, Clone 10F.9G2 ...
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Dendritics.jpg

Dendritics公司主要关注人类树突状细胞,希望找到能够促使CD34+造血前体细胞转化为树突状细胞(在GM-CSF和TNF-alpha存在的情况下)的细胞因子。在1992-2005年间,大量的研究使得研究者对人类树突状细胞的产生、细胞通路、C-type凝集素受体的功能及Toll-like受体的活性有了更深的理解。

 

DENDRITICS was started in 2005 by former members of SCHERING PLOUGH Laboratory for Immunological Research (LIR) in Dardilly, France. From their long experience at LIR, the team members of DENDRITICS have gathered complementary scientific and technological knowledge in different areas of immunology. The initial focus of LIR was in the biology of B lymphocytes, elaboration of human monoclonal antibodies, and in cytokine discovery (IL-3, IL-4, IL-7, IL-10, IL-17, GM-CSF) together with our colleagues of DNAX Research Institute in Palo Alto, California.

 

Our interest in cytokines led to the finding that human dendritic cells (DCs) could be generated in vitro from CD34+ hematopoietic progenitors cultured in the presence of GM-CSF and TNF-alpha.

 

The period from 1992 to 2005 saw the specialization of LIR in DC biology and was fuelled by a large-scale effort to discover and study the function of genes specifically expressed by these cells. This program led to a number of findings that contributed in particular to understanding the heterogeneity of DCs, the pathways regulating DC migration, the function of C-type lectin receptors in DCs and the activity of Toll-like receptors in DCs. Many novel genes were discovered through screening of cDNA libraries or through monoclonal antibodies raised against DCs.

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InVivoPro Rat IgG2a in vivo Isotype control ...
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